SURGICAL TREATMENT OF AN ADVANCED STAGE THYMOMA IN A GOOD’S SYNDROME PATIENT – CASE REPORT

Authors

  • André Sena Department of Cardiothoracic surgery, Hospital de Santa Maria, Lisbon, Portugal
  • Ricardo Ferreira Department of Cardiothoracic surgery, Hospital de Santa Maria, Lisbon, Portugal
  • João Gonçalves Department of Cardiothoracic surgery, Hospital de Santa Maria, Lisbon, Portugal
  • Ângelo Nobre Department of Cardiothoracic surgery, Hospital de Santa Maria, Lisbon, Portugal

DOI:

https://doi.org/10.48729/pjctvs.89

Abstract

We report a rare case of an advanced stage thymoma with right superior pulmonary lobe, superior vena cava, innominate vein and pericardium invasion in a patient with Good’s syndrome. In a multidisciplinary discussion, surgical resection was deemed the best initial approach, since invaded structures could be safely managed. The tumor was fully resected and included partial resection of the superior pulmonary lobe, superior vena cava and innominate vein. The encircled right phrenic nerve was dissected from the tumor and preserved. The superior vena cava and innominate vein were reconstructed using autologous pericardium patch. Immunoglobulin replacement and radiotherapy were initiated afterwards. No signs of relapse at 6 months follow-up. In such advanced cases, aggressive surgical intervention should be considered as first line of treatment, as long as full resection can be anticipated, since complete resection is the leading factor for long-term prognosis.

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References

Kelleher P, Misbah SA. What is Good's syndrome? Immunological abnormalities in patients with thymoma. J Clin Pathol.

;56:12-6.

Venuta F, Anile M, Diso D, Vitolo D, Rendina EA, De Giacomo T, et al. Thymoma and thymic carcinoma. Eur J Cardiothorac

Surg. 2010;37(1):13-25.

Nakamura S, Kawaguchi K, Fukui T, Hakiri S, Ozeki N, Mori S, et al. Multimodality therapy for thymoma patients

with pleural dissemination. Gen Thorac Cardiovasc Surg. 2019;67(6):524-529.

Venuta F, Rendina EA, Coloni GF. Multimodality treatment of thymic tumors. Thorac Surg Clin. 2009;19(1):71-81.

Grassin F, Paleiron N, André M, Caliandro R, Bretel JJ, Terrier P, et al. Combined etoposide, ifosfamide, and cisplatin

in the treatment of patients with advanced thymoma and thymic carcinoma. A French experience. J Thorac Oncol. 2010

Jun;5(6):893-7.

Wright, CD. Pleuropneumonectomy for the treatment of Masaoka stage IVA thymoma. Ann Thorac Surg. 2006;82(4):

-9.

Shudo Y, Takahashi T, Ohta M, Ikeda N, Matsue H, Taniguchi K. Radical operation for invasive thymoma with intracaval, intracardiac, and lung invasion. J Card Surg 2007;22(4):330-2.

Ranucci M, Baryshnikova E. Inflammation and coagulation following minimally invasive extracorporeal circulation technologies. J Thorac Dis. 2019;11(Suppl 10):S1480-S1488.

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Published

25-04-2021

How to Cite

1.
Sena A, Ferreira R, Gonçalves J, Nobre Ângelo. SURGICAL TREATMENT OF AN ADVANCED STAGE THYMOMA IN A GOOD’S SYNDROME PATIENT – CASE REPORT. Rev Port Cir Cardiotorac Vasc [Internet]. 2021 Apr. 25 [cited 2024 Apr. 18];26(4):269-71. Available from: https://pjctvs.com/index.php/journal/article/view/89

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