GIANT PLEURAL TUMOR AND SEVERE HYPOGLYCEMIA: DOEGE-POTTER SYNDROME IN A PREVIOUSLY HEALTHY FEMALE

Authors

  • Nádia Junqueira Serviço de Cirugia Cardiotorácica, Hospital Santa Maria, Lisboa, Portugal
  • João Caldeira Serviço de Cirugia Cardiotorácica, Hospital Santa Maria, Lisboa, Portugal
  • Ricardo Ferreira Serviço de Cirugia Cardiotorácica, Hospital Santa Maria, Lisboa, Portugal
  • Filipe Costa Serviço de Anestesia, Hospital Santa Maria Hospital, Lisboa, Portugal
  • Joana Silva Serviço de Cirugia Cardiotorácica, Hospital Santa Maria, Lisboa, Portugal
  • Teresa Monteiro Serviço de Anestesia, Hospital Santa Maria Hospital, Lisboa, Portugal
  • Ângelo Nobre Serviço de Cirugia Cardiotorácica, Hospital Santa Maria, Lisboa, Portugal

DOI:

https://doi.org/10.48729/pjctvs.38

Abstract

Introduction: Doege–Potter’s syndrome is a rare paraneoplastic syndrome, consisting in hypoglycemia and solitary fibrous tumor of the pleura. These tumors represent <5% of all pleural tumours and can only be cured by surgery. In this article, we report a case of a patient presenting with severe hypoglycemia, as the only symptom, and a mass occupying the entire left hemithorax.

Case presentation: A54 year old female with severe hypoglycemia, a chest radiography with almost total opacification of the left hemithorax and a computed tomography scan with a mass in the left hemithorax. Surgery was performed and a mass with 30cm × 18cm × 11cm weighing 3195g was resected. The postoperative course was uneventful with immediate resolution of the hypoglycemia. The immunohistochemistry diagnosis was solitary fibrous tumor of the pleura.

Conclusions: Solitary fibrous tumor of the pleura are very rare. Less than 5% are associated with hypoglycemia, taking the form of Doege-Potter Syndrome. Radiation therapy and chemotherapy have shown low response rate and complete surgical resection is the only procedure that offers cure. This case reports describes a rare giant solitary fibrous tumor of the pleura with severe hypoglycemia, successfully treated by surgery. Long-term follow-up of the patient after the surgery is necessary for detection of any possible recurrence.

Downloads

Download data is not yet available.

References

- Fengwei T, Yalong W, Shugeng G, Qi X, Juwei M, Yousheng M, et al. Solitary fibrous tumors of the pleura: A single center. Thoracic Cancer 9 (2018) 1763–1769.

- Furukawa N, Hansky B, Niedermayer J, Gummert J, Renner A. A silent gigantic fibrous tumor of the pleura: case report. J CardiothoracSurg 2011;6:122–6.

- Walid AA. Solitary fibrous tumors of the pleura. Eur J CardiothoracSurg 2012;41:587–97.

- Perna V, Rivas F, Morera R, Saumench J, Ramos R, Macia I, et al. Localized (solitary) fibrous tumors of the pleura: an analysis of 15 patients, Int. J. Surg. 6 (2008) 298–301.

- Raafat E, Karunasiri D, Kamangar N. Solitary fibrous tumour of the pleura presenting as a giant intrathoracic mass, Case report. BMJ Case Rep 2017. doi:10.1136/bcr-2017-220695.

- Davanzo B, Emerson R, Lisy M, Koniaris L, Kays J. Solitary fibrous tumor. TranslGastroenterolHepatol 2018;3:94.

- Perrot M, Fischer S, Bründler M, Sekine Y, Keshavjee S. Solitary fibrous tumors of the pleura, Ann. Thorac. Surg. 74 (2002) 285–293.

- Perrot M, Fischer S, BruÃàndler A, Sekine Y, Keshavjee S. Solitary fibrous tumors of the pleura, Ann. Thorac. Surg. 74 (2002) 285-293.

- Groot JW, Rikhof B, Doorn J, Bilo HJ, Alleman MA, Honkoop AH, Graaf WT. Non-islet cell tumor-induced hypoglycaemia: a review of the literature including two new cases. EndocrRelat Cancer, 2007, 14(4):979–993.

Downloads

Published

17-04-2021

How to Cite

1.
Junqueira N, Caldeira J, Ferreira R, Costa F, Silva J, Monteiro T, Nobre Ângelo. GIANT PLEURAL TUMOR AND SEVERE HYPOGLYCEMIA: DOEGE-POTTER SYNDROME IN A PREVIOUSLY HEALTHY FEMALE. Rev Port Cir Cardiotorac Vasc [Internet]. 2021 Apr. 17 [cited 2022 Dec. 8];27(3):223-6. Available from: https://pjctvs.com/index.php/journal/article/view/38

Issue

Section

Clinical Cases

Most read articles by the same author(s)

1 2 > >>