LUNG RESECTION FOR NON-SMALL-CELL LUNG CANCER - A NEW RISK SCORE TO PREDICT MAJOR PERIOPERATIVE COMPLICATIONS

Authors

  • Paulo Veiga Oliveira Department of Cardiothoracic Surgery, Santa Cruz Hospital, Lisbon, Portugal https://orcid.org/0000-0001-8360-1714
  • Daniel Cabral Department of Thoracic Surgery, Pulido Valente Hospital, Lisbon, Portugal
  • Mariana Antunes Department of Thoracic Surgery, Pulido Valente Hospital, Lisbon, Portugal
  • Carolina Torres Department of Thoracic Surgery, Pulido Valente Hospital, Lisbon, Portugal
  • Magda Alvoeiro Department of Thoracic Surgery, Pulido Valente Hospital, Lisbon, Portugal
  • Cristina Rodrigues Department of Thoracic Surgery, Pulido Valente Hospital, Lisbon, Portugal
  • Miguel Sousa-Uva Department of Cardiothoracic Surgery, Santa Cruz Hospital, Lisbon, Portugal
  • Francisco Félix Department of Thoracic Surgery, Pulido Valente Hospital, Lisbon, Portugal

DOI:

https://doi.org/10.48729/pjctvs.221

Keywords:

Risk score, Major perioperative complications, Non-small-cell lung cancer

Abstract

Objectives: Identify risk factors for major perioperative complications (MPC) after anatomical lung resection for NonSmall-Cell Lung Cancer (NSCLC) and establish a scoring system.

Methods: Single center retrospective study of all consecutive patients diagnosed with NSCLC submitted to anatomical lung resection from 2015 to 2019 (N=564). Exclusion criteria: previous lung surgery, concomitant non-lung cancer related procedures, urgency surgery. Study population: 520 patients. Primary end-point: MPC defined as a composite endpoint including at least one of the in-hospital complications. Univariable and Multivariable analyses were developed to identify predictors of perioperative complications and create a risk score. Discrimination was assessed using the C-statistic. Calibration was evaluated by Hosmer and Lemeshow test and internal validation was obtained by means of bootstrap replication.

Results: Mean age of 65 years and 327 (62.9%) were males. Mean hospital stay of 9 days after surgery. Overall MPC rate was 23.3%. Male gender, hypertension, FEV1<75%, thoracotomy, bilobectomy/pneumectomy and additional resection were independent predictors of MPC. A risk score based on the odds ratios was developed - Major Perioperative Complications of Lung Resection (MPCLR) scoring system - and ranged between 0 and 14 points. It was divided in 5 groups: 1-2 points (positive preditive value 15%); 3-4 (PPV 25%); 5-7 (PPV 35%); 8-9 (PPV 60%); >10 points (PPV 88%). The score showed rea- sonable discrimination (C-statistic=0.70), good calibration (P=.643) and it was internally validated (C-statistic=0,70 BCa95% CI,0.65-0.79).

Conclusions: This study proposes a simple and daily-life risk score system that was able to predict the incidence of perioperative complications.

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References

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Published

04-01-2022

How to Cite

1.
Veiga Oliveira P, Cabral D, Antunes M, Torres C, Alvoeiro M, Rodrigues C, Sousa-Uva M, Félix F. LUNG RESECTION FOR NON-SMALL-CELL LUNG CANCER - A NEW RISK SCORE TO PREDICT MAJOR PERIOPERATIVE COMPLICATIONS. Rev Port Cir Cardiotorac Vasc [Internet]. 2022 Jan. 4 [cited 2022 Jan. 28];28(4):31-6. Available from: https://pjctvs.com/index.php/journal/article/view/221

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