EXTRACORPOREAL MEMBRANE OXYGENATION SUPPORT FOR POSTCARDIOTOMY SHOCK: SINGLE CENTER EXPERIENCE

Authors

  • Manuela Silva Department of Cardiothoracic Surgery
  • Carolina Rodrigues Department of Cardiothoracic Surgery, Santa Marta Hospital, Centro Hospitalar Universitário Lisboa Centro, Lisbon, Portugal
  • Tiago Silva Department of Cardiothoracic Surgery, Santa Marta Hospital, Centro Hospitalar Universitário Lisboa Centro, Lisbon, Portugal
  • Pedro Coelho Department of Cardiothoracic Surgery, Santa Marta Hospital, Centro Hospitalar Universitário Lisboa Centro, Lisbon, Portugal
  • Nuno Banazol Department of Cardiothoracic Surgery, Santa Marta Hospital, Centro Hospitalar Universitário Lisboa Centro, Lisbon, Portugal
  • Rui Rodrigues Department of Cardiothoracic Surgery, Santa Marta Hospital, Centro Hospitalar Universitário Lisboa Centro, Lisbon, Portugal
  • Paulo Franco Department of Cardiothoracic Surgery, Santa Marta Hospital, Centro Hospitalar Universitário Lisboa Centro, Lisbon, Portugal
  • José Fragata Department of Cardiothoracic Surgery, Santa Marta Hospital, Centro Hospitalar Universitário Lisboa Centro, Lisbon, Portugal

DOI:

https://doi.org/10.48729/pjctvs.10

Abstract

Objectives: We aim to report our experience on venoarterial extracorporeal membrane oxygenation (VA-ECMO) for postcardiotomy shock (PCS).

Methods: Single center, retrospective study of all patients on VA-ECMO for PCS, from November 2006 to July 2019. Pediatric and adult patients were analysed separately. Primary outcomes were survival to discharge and one-year survival.

Results: Twenty-nine patients were included. Pediatric group (group PED) (62%, n=18): mean age 1,3±2,1 years and 39% male. Adults (group AD) (38%, n=11): mean age 55,6±15,9 years and 64% male. Indications in group PED were complex congenital heart surgery (94%) and heart transplant (6%), with 27% being reoperations; in group AD valvular surgery (45%), aortic surgery (21%), coronary artery bypass grafting (18%) and pulmonary endarterectomy (9%); 45% were reoperations. ECMO support was initiated intraoperatively due to failure to wean from cardiopulmonary bypass in 28% of group PED and 73% of group AD. Central cannulation was performed in all pediatric patients and 82% adults. Bleeding was the most common complication in both groups (group PED 39%, group AD 45%). Mean ECMO support time was respectively 6,2±4,9 and 6,2± 3,6 days for group PED and group AD. Weaning rate was 44% in group PED (with 2 patients bridged to LVAD) and 45% in group AD. Survival to discharge as well as one-year survival were both 28% in group PED and 18% in group AD.

Conclusion: Despite low survival and high complication rates, VA ECMO support provides a survival benefit in refractory cases, with a dismal prognosis, that would otherwise die.

Downloads

Download data is not yet available.

References

Lorusso R, Raffa GM, Alenizy K, Sluijpers N, Makhoul M, Brodie D, McMullan M, Wang IW, Meani P, MacLaren G, Kowalewski M, Dalton H, Barbaro R, Hou X, Cavarocchi N, Chen YS, Thiagarajan R, Alexander P, Alsoufi B, Bermudez CA, Shah AS, Haft J, D'Alessandro DA, Boeken U, Whitman GJR. Structured review of post-cardiotomy extracorporeal membrane oxygenation: part 1-Adult patients. J Heart Lung Transplant. 2019 Nov;38(11):1125-1143.

Meani P, Matteucci M, Jiritano F, Fina D, Panzeri F, Raffa GM, Kowalewski M, Morici N, Viola G, Sacco A, Oliva F, Alyousif A, Heuts S, Gilbers M, Schreurs R, Maessen J, Lorusso R. Long-term survival and major outcomes in post-cardiotomy extracorporeal membrane oxygenation for adult patients in cardiogenic shock. Ann Cardiothorac Surg. 2019 Jan;8(1):116-122.

Khorsandi M, Dougherty S, Sinclair A, Buchan K, MacLennan F, Bouamra O, Curry P, Zamvar V, Berg G, Al-Attar N. A 20-year multicentre outcome analysis of salvage mechanical circulatory support for refractory cardiogenic shock after cardiac surgery. J Cardiothorac Surg. 2016 Nov 8;11(1):151.

Rihal CS, Naidu SS, Givertz MM, Szeto WY, Burke JA, Kapur NK et al. 2015 SCAI/ACC/HFSA/STS Clinical Expert Consensus Statement on the Use of Percutaneous Mechanical Circulatory Support Devices in Cardiovascular Care: Endorsed by the American Heart Assocation, the Cardiological Society of India, and Sociedad Latino Americana de Cardiologia Intervencion; Affirmation of Value by the Canadian Association of Interventional

Cardiology-Association Canadienne de Cardiologie d’intervention. J Am Coll Cardiol 2015;65:e7–26.

Biancari F, Dell'Aquila AM, Mariscalco G. Predicting mortality after postcardiotomy venoarterial extracorporeal membrane oxygenation. Ann Transl Med. 2019;7(Suppl 3):S100.

Barge-Caballero E, Almenar-Bonet L, Gonzalez-Vilchez F, Lambert-Rodríguez JL, González-Costello J, Segovia-Cubero J, Castel-Lavilla MA, Delgado-Jiménez J, Garrido-Bravo IP, Rangel-Sousa D, Martínez-Sellés M, De la Fuente-Galan L, Rábago-Juan-Aracil G, Sanz-Julve M, Hervás-Sotomayor D, Mirabet-Pérez S, Muñiz J, Crespo-Leiro MG. Clinical outcomes of temporary mechanical circulatory support as a direct bridge

to heart transplantation: a nationwide Spanish registry. Eur J Heart Fail. 2018 Jan;20(1):178-186.

Bellumkonda L, Gul B, Masri SC. Evolving concepts in diagnosis and management of cardiogenic shock. Am J Cardiol 2018;122:1104-10.

Whitman GJR. Extracorporeal membrane oxygenation for the treatment of postcardiotomy shock. J Thorac Cardiovasc Surg 2017; 153:95-101.

Lorusso R, Whitman G, Milojevic M, Raffa G, McMullan DM, Boeken U, Haft J, Bermudez CA, Shah AS, D'Alessandro DA. 2020 EACTS/ELSO/STS/AATS expert consensus on post-cardiotomy extracorporeal life support in adult patients. Eur J Cardiothorac Surg. 2021 Jan 4;59(1):12-53.

Elsharkawy HA, Li L, Esa WAS, Sessler DI, Bashour CA. Outcome in Patients Who Require Venoarterial Extracorporeal Membrane Oxygenation Support After Cardiac Surgery. J Cardio-Thorac Vasc Anesth 2010;24:946-51.

Pokersnik JA, Buda T, Bashour CA, Gonzalez-Stawinski GV. Have changes in ECMO technology impacted outcomes in adult patients developing postcardiotomy cardiogenic shock? J Card Surg 2012;27:246-52.

Mikus E, Tripodi A, Calvi S, et al. CentriMag venoarterial extracorporeal membrane oxygenation support treatment for patients with refractory postcardiotomy cardiogenic shock. ASAIO J 2013;59:18-23.

Unosawa S, Sezai A, Hata M, et al. Long-term outcomes of patients undergoing extracoporeal membrane oxygenation for refractory postcardiotomy cardiogenic shock. Surg Today 2013;43:264-70.

Ariyaratnam P, McLean LA, Cale ARJ, Loubani M. Extra-corporeal membrane oxygenation for the post-cardiotomy patient. Heart Fail Rev 2014;19:717-25.

Li CL, Wang H, Jia M, et al. The early dynamic behavior of lactate is linked to mortality in postcardiotomy patients with extracorporeal membrane oxygenation support: a retrospective observational study. J Thorac Cardiovasc Surg 2015;149:1445-50.

Saxena P, Neal J, Joyce LD, et al. Extracorporeal membrane oxygenation support in postcardiotomy elderly patients: the Mayo Clinic experience. Ann Thorac Surg 2015;99:2053-60.

Biancari F, Perrotti A, Dalén M, Guerrieri M, Fiore A, Reichart D et al. Meta-Analysis of the Outcome After Postcardiotomy Venoarterial Extracorporeal Membrane Oxygenation in Adult Patients. J Cardiothorac Vasc Anesth. 2018 Jun;32(3):1175-1182.

Hsu PS, Chen JL, Hong GJ, et al. Extracorporeal membrane oxygenation for refractory cardiogenic shock after cardiac surgery:

predictors of early mortality and outcome from 51 adult patients. Eur J Cardiothorac Surg 2010;37:328-33.

Rastan AJ, Lachmann N, Walther T, et al. Autopsy findings in patients on postcardiotomy extracoporeal membrane oxygenation. Int J Artif Organs 2006;29:1121-31.

Unosawa S, Sezai A, Hata M, Nakata K, Yoshitake I, Wakui S et al. Long term outcomes of patients undergoing extracorporeal membrane oxygenation for refractory postcardiotomy cardiogenic shock. Surg Today 2013;43:264–70.

Rastan AJ, Dege A, Mohr M, Doll N, Falk V, Walther T et al. Early and late outcomes of 517 consecutive adult patients treated with extracorporeal membrane oxygenation for refractory postcardiotomy cardiogenic shock. J Thorac Cardiovasc Surg 2010;139:302–11,11.e1.

Po-Shun Hsu, Jia-Lin Chen, Guo-Jieng Hong, Yi-Ting Tsai, Chih-Yuan Lin, Chung-Yi Lee, Yu-Guang Chen, Chien-Sung Tsai, Extracorporeal membrane oxygenation for refractory cardiogenic shock after cardiac surgery: predictors of early mortality and outcome from 51 adult patients, Eur J Cardiothorac Surg 2010, Vol 37, Issue 2, 328–333.

Lo Coco V, Lorusso R, Raffa GM, Malvindi PG, Pilato M, Martucci G et al. Clinical complications during veno-arterial extracorporeal membrane oxigenation in post-cardiotomy and non post-cardiotomy shock: still the achille’s heel. J Thorac Dis. 2018 Dec;10(12):6993-7004.

Extracorporeal Life Support Organization. Risks and complications. https://www.elso.org/Resources/RisksandComplications.aspx (9 December 2020, date last accessed).

Burrell AJC, Bennett V, Serra AL, Pellegrino V, Romero L , Fan E et al. Venoarterial extracorporeal membrane oxygenation: A systematic review of selection criteria, outcome measures and definitions of complications. J Crit Care. 2019 Oct;53:32-37.

Downloads

Published

08-04-2021

How to Cite

1.
Silva M, Rodrigues C, Silva T, Coelho P, Banazol N, Rodrigues R, Franco P, Fragata J. EXTRACORPOREAL MEMBRANE OXYGENATION SUPPORT FOR POSTCARDIOTOMY SHOCK: SINGLE CENTER EXPERIENCE. Rev Port Cir Cardiotorac Vasc [Internet]. 2021 Apr. 8 [cited 2024 Dec. 26];28(1):25-9. Available from: https://pjctvs.com/index.php/journal/article/view/10

Issue

Section

Original Articles

Most read articles by the same author(s)