Lemierre Syndrome: Clinical Challenges And The Anticoagulation Dilemma In Adolescent Care
DOI:
https://doi.org/10.48729/pjctvs.436Keywords:
Lemierre Syndrome, Thrombophlebitis, Embolism, Palatine TonsilAbstract
Lemierre syndrome is a rare, life-threatening condition characterized by an acute otorhinolaryngologic infection with septic thrombophlebitis of the internal jugular vein and septic embolism, particularly to the lungs. We describe a case of a previously healthy 15-year-old female patient who initially presents fever and odynophagia but quickly develops neck and pleuritic chest pain. Computed tomography was performed and the radiological findings confirmed the diagnosis of a Lemierre syndrome. She was managed with antibiotics, anticoagulant for three days and symptomatic treatment, with a gradually improving condition. After 17 days of hospitalisation, due to reappearance of pleuritic pain, a new imaging assessment was performed and showed additional septic emboli in the lungs, which prompted the reintroduction of anticoagulant therapy. Awareness of the existence of this syndrome is essential to ensure a radiological evaluation with computed tomography and thus timely diagnosis and treatment.
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References
Osowicki J, Kapur S, Phuong LK, Dobson S. The long shadow of Lemierre’s syndrome. Journal of Infection. 2017;74:S47-S53.
Valerio L, Corsi G, Sebastian T, Barco S. Lemierre syndrome: Current evidence and rationale of the Bacteria-Associated Thrombosis, Thrombophlebitis and LEmierre syndrome (BATTLE) registry. Thrombosis research. 2020;196:494-9.
Lee W-S, Jean S-S, Chen F-L, Hsieh S-M, Hsueh P-R. Lemierre's syndrome: a forgotten and re-emerging infection. Journal of Microbiology, Immunology and Infection. 2020;53(4):513-7.
Gore MR. Lemierre syndrome: a meta-analysis. International Archives of Otorhinolaryngology. 2020;24(03):e379-e85.
Nygren D, Elf J, Torisson G, Holm K, editors. Jugular vein thrombosis and anticoagulation therapy in Lemierre’s syndrome—a post hoc observational and population-based study of 82 patients. Open forum infectious diseases; 2021: Oxford University Press US.
Kuppalli K, Livorsi D, Talati NJ, Osborn M. Lemierre's syndrome due to Fusobacterium necrophorum. The Lancet infectious diseases. 2012;12(10):808-15.
Ridgway JM, Parikh DA, Wright R, Holden P, Armstrong W, Camilon F, et al. Lemierre syndrome: a pediatric case series and review of literature. American journal of otolaryngology. 2010;31(1):38-45.
Phua C, Chadachan V, Acharya R. Lemierre syndrome—should we anticoagulate? A case report and review of the literature. International Journal of Angiology. 2013:137-42.
Valerio L, Zane F, Sacco C, Granziera S, Nicoletti T, Russo M, et al. Patients with Lemierre syndrome have a high risk of new thromboembolic complications, clinical sequelae and death: an analysis of 712 cases. Journal of internal medicine. 2021;289(3):325-39.
Lu MD, Vasavada Z, Tanner C. Lemierre syndrome following oropharyngeal infection: a case series. The Journal of the American Board of Family Medicine. 2009;22(1):79-83.
Bondy P, Grant T. Lemierre's syndrome: what are the roles for anticoagulation and long-term antibiotic therapy? Annals of Otology, Rhinology & Laryngology. 2008;117(9):679-83.
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